AFFECT OF GUIDE TREES ON MULTIPLE SEQUENCE ALIGNMENT

In this paper we are proving that in context to the multiple sequence alignment formation of guide tree is an important step. Most MSA tools use guide trees to do alignment of multiple sequences. Here we have implemented an algorithm that generates guide trees given some sequences. These user generated guide trees are then used to do multiple sequence alignment to study the impact of guide trees on MSA against already existing MSA tools. We observe that better guide trees can result in better alignment with improved accuracy.