HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC ACTIVITY OF SYZYGIUM ALTERNIFOLIUM (WT.) WALP. LEAF EXTRACTS IN NORMAL AND DIABETIC RATS.

Aqueous, ethanolic and chloroform fraction of Syzygium alternifolium leafs were prepared and given dif erentdoses of these extracts individually to dif erent batches of rats (both normal and alloxan induced diabetic rats)after an overnight fast. The blood glucose levels were measured at 0, 1, 3, 5 and 7 hours after the treatment. Theethanol extract of Syzygium alternifolium at a dosage of 0.75 g/kg b.w. is showing maximum blood glucoselowering ef ect in both normal and alloxan induced diabetic rats. The aqueous and chloroform fractions arealso showing hypoglycemic and antihyperglycemic activity, but the ef ect is significantly less than that ofethanol extract. The antihyperglycemic activity of Syzygium alternifolium leafs was compared with thetreatment of Glibenclamide