Enantioselective total synthesis of (R)-( )-complanine

A route is described for the enantioselective synthesis of (R)-( )-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.