Antihepatotoxic and antioxidant defense potential of Mimosapudica

Reactive Oxygen species (ROS) are believed to be responsible for pathogenesis of variousdiseases affecting tissues and the main organ, the Liver. Hence, in the present study, the extent of LipidPeroxidation (LPO) and ROS elimination and its defense mechanisms by the enzymic & non enzymicantioxidants in liver & serum was investigated. Hepatoxicity was manifested by significantly decreased(p<0.05) levels in the activities of the enzymic antioxidants such as Superoxide dismutase (SOD) Catalase(CAT), Glutathione peroxidase and the non enzymic antioxidants such as glutathione & Vitamin C in ratsinduced hepatic damage by ethanol Simultaneous administration of the leaf extract Mimosa pudica alongwith the toxin ethanol in rats showed a considerable protection against the toxin induced oxidative stressand liver damage as evidence by a significant increase (p<0.05) in antioxidant activities. The study revealsthat the co administration of Mimosa pudica aqueous extract significantly lowered the level of lipidperoxidation in alcohol fed mice.