IMPROVEMENT OF BLOOD-BRAIN BARRIER AND ANTIOXIDANT ENZYME ACTIVITIES BY IMMUNOX V DRUG IN MENINGITIS

The aim of the present study was investigated the improvement of antioxidant enzymes activities and bloodbrain barrier by Immunox V drug in cerebral spinal fluid of meningitis induced rat model. Twenty four albinorats were selected and divided into three groups of eight; Control group (n=8), Infected group (n=8) andImmunox V treated group (n=8). Our results showed that there were significantly (p<0.001) decreased in allantioxidant enzymes activities along with increased the activities of adenylate kinase, xanthine oxidase enzymes(p<0.001) as well as malonaldialdehyde (MDA) levels in the CSF of infected group as compared to control group.The levels of total protein, calcium and phosphorus were also increased significantly (p<0.001) along withdecreased (p<0.001) the glucose level in CSF of infected group as compared to control group. Afteradministration of immunox V for one week treatment, all enzyme activities along with MDA levels as well asbiochemical parameters were improved and come back to normal level in the infected plus treated group. Thesefindings indicated that immunox V drug play a therapeutic role in the improvement of oxidant and antioxidantlevels and prevent the blood brain barrier during bacterial meningitis infection.