Homozygous hemoglobin D with alpha thalassemia: case report

Hb D is a clinically silent condition, but co-inheritance of Hb D with sickle cell or thalassemia produces clinically significant conditions like sickle cell anemia or thalassemia intermedia and chronic hemolytic anemia of moderate severity. Here we present a case of homozygous Hb D with alpha 3.7kb deletion and phenotypic effect on patients. Diagnosis of Hb D patient was performed by high performance liquid chromatography (HPLC) and complete blood count was measured by automated cell analyzer. Molecular study for common alpha deletions done by Gap-PCR. A homozygous Hb D patient with alpha thalassemia was present mild clinical manifestations with normal reticulocytes and red cell indices. Thus observed case conclude the co-existence of alpha 3.7 deletions with homozygous Hb D present mild clinical – hematological picture.