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OALib Journal期刊
ISSN: 2333-9721
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Determination of Synthetic Precursors as Impurities in Diclofenac Sodium Raw Material

Keywords: Diclofenac Na , Precursors , Impurities , HPLC

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Abstract:

Impurities of drug substances may produce some side effects in patient. Diclofenac Na is a member of non-steroidal anti inflammatory drugs (NSAIDs) family, which is routinely used bypatients for the treatment of rheumatoid arthritis and various pains. To develop a method for the determination of synthetic precursors which could be remained as impurities in raw drugmaterials, Na diclofenac powder was chosen in this study. High performance liquid chromatography was used to detect and separate diclofenac from its usual precursors. The chromatographic conditions were as follows: column; C18, mobile phase; methanol/water (55/45), flow rate; 1 ml/min, wavelength of detector; 254nm. The chromatogram obtained showed a reasonabl e separations of Na di clofenac and its precursors. This method of analysis is applicable in the final product inspection of Na diclofenac raw material

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