Evaluation of the Side Effects of Triple Vaccine in Yazd in 2005

Background: Simultaneous immunization against diphtheria, tetanus and pertussis during infancy and childhood has been a routine practice in Iran. Considering the role of triple vaccine in reduction of mortality as a result of disastrous diseases such as diphteria, tetanus, and pertussis. We have little information on the incidence of its complications in Yazd. This study was performed to determine the complications of triple vaccine in the health centers of Yazd in 2005. Methods: The descriptive strategy of this study was carried out on 474 cases from 1.5 month to 6 years old. All of them were carefully examined up to 72h for the occurrence of complications and the observed symptoms were collected in a questionnaire and the data were analyzed. Findings: The incidence rate of complications after injection of triple vaccine was 81.4%. In this study fever, pain at the injection site, swelling, crying, loss of appetite, irritability, erythema, and vomiting were 56.8%, 55%, 26.8%, 11.4%, 11.2%, 11%, 10.5% and 6.5%, respectively. Conclusion: Due to the high incidence rate of complications after injection of triple vaccine, we recommend acetaminophen prophylacticly after vaccination.