The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients

Backgroundβ Thalassemic children have oxidative stress and antioxidant deficiency even without ironoverload status. In these patients, tissue damage due to oxidative stress may be occurred. Also, itseems that thalassemic patients have higher levels of ALT, AST therefore, the main aim of thepresent study was to determine the benefits of vitamin E as an antioxidant supplements in β-Thalassemia children.Materials and MethodsThis clinical trial was carried out on 45 beta-thalassemic patients undergoing occasionaltransfusions (24 males, 21 females), mean age 16± 8 years, admitted to Yazd and ShahidSadoughi hospital in 2011. Fallowing three months treatment of vitaminE (vitamin E 400-600unit/day),liver function test and hemopoitic system parameters were measured.ResultsFourty five patients with laboratory confirmation of β-Thalassemia were recruited followingthree months vitamin E supplementation, liver function test had higher improvement comparedto hemopoitic system parameters , and also serum SGOT was significantly reduced (Pvalue<0.004 ).ConclusionIt seems clear that treatments of β-thalassemic patients with vitamins E have benefits inpromoting antioxidant status and may improve liver function test, as AST and ALT to decreasebut this supplement is not effective for hemopoietic system variables.