Histological evaluation of Accell Connexus and Bio-Oss on quality and rate of bone healing: a single blind experimental study on rabbit’s calvarium

Objective: The objective of this study was to evaluate the effect of Accell Connexus on the quality and rate of healing in experimental defects of rabbit calvarium compared to Bio-Oss .Materials and Methods: Twelve 2.5-3.5 kg weighing New Zealand white rabbits were used. Three defects (3×6 mm) were created in the cranium of the animals subsequently filled with Accell Connexus , Bio-Oss or served as controls. The animals were sacrificed four, six and eight weeks postoperatively and the histology blocks were studied in terms of inflammation, trabeculation thickness, bone type regeneration, foreign body and remained biomaterial by light microscope. The data were subject to Mann-Whitney U test.Results: Increased inflammatory reaction, foreign body reaction, delayed bone formation and lower rate of ossification were observed in DBM-filled defects compared to Bio-Oss or controls. However, no significant differences were observed in bone formation between Bio-Oss , Accell Connexus and control specimens in the three time intervals. Furthermore, no significant differences were noted between Bio-Oss and control groups.Conclusion: Accell Connexus showeda lower rate of ossification and bone healing compared to Bio-Oss or controlgroups.Other studies in this field seem necessary.