Amyotrophic lateral sclerosis with laboratory abnormalities of uncertain significance: A brief review

Amyotrophic lateral sclerosis (ALS), the most common formof motor neuron disease, is a progressive and devastatingdisease involving both lower and upper motor neurons,typically following a relentless progression towards death.Therefore, all efforts must be made by the clinician toexclude alternative and more treatable entities. ALS withlaboratory abnormalities of uncertain significance is asubgroup of ALS that occurs in association with laboratorydefined abnormalities that are of uncertain significance tothe pathogenesis of ALS. The clinical utility of theseabnormalities and what they ultimately mean in patientswith ALS is discussed here, along with a review of theliterature.