Involvement of N6 and N3 polyunsaturated faty acids on the lipidic profile in central nervous system of the animals of experience

Introduction: N-3 and N-6polyunsaturated fatty acids has manyinvolvements in activities within orentering in regulating various physiologicalprocesses and in certain pathologies.Among systemic physiological effects inwhich they are involved we mention thecentral nervous system development andrecall of the retina, regulating plasma lipidlevels, cardiovascular and immune systemfunctions, regulating the activity of insulin.Material and methods: The experimentthere were used 60 male Wistar rats , weight180 ± 20 grams, procured from the animalfarm of the Department ofPathophysiology, University of Medicineand Pharmacy “Gr.T. Popa”, Ia i.Male Wistar rats were divided into twostudy groups: normal control animals (M)and test animals.Test group was further divided intothree groups - each group being composedof 15 animals.Administration of the substances wasmade for 36 weeks (nine months), afterwhich the animals were evaluated andsubsequently sacrificed.Results: Following statistical analysis, wedetermined the following: Averages of AGP n3 were significantlyhigher in groups 2 (p <0.001) and 3 (p<0.001) compared with group 4 Averages ratio n6: n3 in nerve cellmembrane were significantly lower ingroups 2 (p <0.001) and 3 (p <0.001)compared with group 4Discussions: Our experimentdemonstrates that increased amounts ofpolyunsaturated fatty acids in themembranes of nerve cells which can justifythe positive evolution of animals inassessing the performance of concomitantbehavioral tests.Conclusions: This study brings new lighton the importance of the existence of abalance between PUFA intake and dailydiet.