Evidence-based pain management: is the concept of integrative medicine applicable?

The problem of pain remains to be very common in the society, impacts on the disease intercourse, and patients' life quality. The concept for predictive, preventive, and personalized medicine cannot be entirely realized without consideration of adequate physiological integrative management of pain in medicine of the future. Existing treatment pain protocols leave a minor physiological relevance and personalized orientation (e.g., medication treatment). Pharmacological schemes are mostly directed to pain relief, do not suggest solution of the basic problem of pain treatment, and pose other challenges for the patient's health. Predictive schemes still lack in healthcare systems; the opportunities of routine clinical utilization of advanced technological approaches and analytics for diagnosis and prediction disorders, related to peripheral nervous system and neuro-muscular junctions, are still not applied commonly. Particular studies and practical approaches in these directions are mostly disintegrated. Despite the large number of preventive programs in rehabilitation and sport medicine, they require higher level of scientific basis for personalized adaptation. The novel predictive, preventive, and personalized medicine (PPPM) activity will increase a part of physically active contributing members of the society in elderly age in good physical and mental health [1,2], providing a complex performance of the proposed programs to actualize the ‘three-dimensional’ PPP vision in medical approaches declared by the European Association for Predictive, Preventive and Personalized Medicine (EPMA). Traditional medicine prevention strategies may provide some answers to the difficulties faced by healthcare systems considering the human being as a physical, psychological, and spiritual entity for individualized treatment algorithms and medical approaches tailored to the patient in the concept of person-centered medicine within EPMA [3-5].In the structure of the pain morbidity, the