Higher mortality of patients on haemodialysis with pancreatic diabetes compared to type 2-diabetes

In a retrospective study we evaluated 96 diabetic patients, who started hemodialysis (HD) in our dialysis centre (1997-2005). In 12 patients PMD was diagnosed, and 84 patients had type 2 diabetes. In both groups we compared vascular risk factors and prevalence of vascular diseases at the start of dialysis. We also evaluated incidence of malnutrition, and 5-year survival in both patient groups.The vascular risk factors were similar in both patient groups, also the prevalence of vascular diseases at the initiation of HD was similar in both groups. In the patients with PDM the mean BMI (kg/m2) was lower (22 + 3 versus 25 + 3), and also their serum albumin was lower (2.7 + 0.3 versus 3.4 + 0.3 g/dl, p < 0.05). Four of these patients (33%) developed malnutrition (BMI < 18.5). In the patients with PDM the age adjusted 5-year survival was significantly lower (8% versus 27%, p < 0.05) than in the type 2 diabetic patients.Conclusions in HD-treated patients with type 2 diabetes or PDM the prevalence of vascular diseases was not significantly different. The lower survival of PDM patients can be related to poor nutrition status.In rare cases (1-8%) patients w/ith pancreatic diabetes (PDM) develop diabetic nephropathy (dNP) with ESRD [1-4] The aim of this retrospective study was to investigate differences in the clinical outcome of uremic patients with dNP due to type 2 diabetes or PDM. There are only few data in the literature dealing with PDM and ESRD [3]. In a recent study was reported, that only 1-5% of diabetic patients with ESRD suffer from pancreatic diabetes [Choudhuri et al. 2009]. Aim of our study was to investigate prevalence of atherosclerosis and to evaluate differences in the outcome of patients with PDM and those with type 2 diabetes.During the years 1997-2005 we selected 144 type 2 diabetic patients who started chronic hemodialysis (HD) in our dialysis centre. We excluded patients with death within the first three months of HD (n = 24), kidney transplantation (n