Metabolic syndrome correlates intracoronary stenosis detected by multislice computed tomography in male subjects with sleep-disordered breathing

The study (O-VFStudy) subjects were 39 Japanese men with SDB/OSA who underwent all-night cardiorespiratory monitoring with fully attended polysomnography, and moreover both fat computed tomography (CT) scan and 64-row MSCT coronary angiography. The prevalence of coronary stenosis in this selected population with SDB/OSA was 15%. Logistic regression analysis showed a significant relationship between age-adjusted CAD and metabolic syndrome (p < 0.05), but not serum adiponectin levels and nocturnal fall in adiponectin. Subjects with the metabolic syndrome had significantly higher prevalence of CAD (31.3 versus 4.3%, p = 0.033), and lower levels of serum adiponectin (4.5 ± 0.6 versus 6.4 ± 0.6 μg/mL, p = 0.014), compared with groups without the metabolic syndrome.The present study describes that the prevalence of greater than 50% intracoronary stenotic lesions detected by MSCT was 15% and the metabolic syndrome was correlated with intracoronary stenosis detected by MSCT in Japanese SDB/OSA subjects.UMIN 000002997https:/ / upload.umin.ac.jp/ cgi-open-bin/ ctr/ ctr.cgi?function=brows&action=brows &type=summary&recptno=R000003633&la nguage=E webcite.Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), is a potential risk factor for cardiovascular diseases, including coronary artery disease (CAD) and stroke [1-3]. OSA is common in middle-age men [4], and frequent complications include hypertension, dyslipidemia and insulin resistance based on abdominal obesity or excess visceral fat [5-8]. Visceral fat is a huge endocrine organ producing a variety of bioactive substances, conceptualized as 'adipocytokines' [9]. Our group discovered adiponectin as an adipocytokine in the human adipose cDNA library [10], which has anti-atherosclerotic property [11]. We have recently demonstrated that, 1) production of adiponectin is dysregulated in intra-abdominal obese patients with severe OSA [12,13], and 2) night-time onset of acute coronary syndrome is associated wi