Cardiac arrest following a glucose 30% bolus: what happened?

One hour later hypoglycemia was detected, and 20 ml of 30% glucose was given intravenously. At the end of the injection, ventricular fibrillation developed. Cardiopulmonary resuscitation successfully restored adequate circulation within 12 minutes. Blood analysis performed using an ABL 700 (Radiometer, Copenhagen, Denmark) 1 minute after beginning cardiac resuscitation showed serum potassium of 5.1 mmol/l, ionised calcium of 1.1 mmol/l, and serum sodium of 140 mmol/l. The empty ampoule was checked, and had contained the correct solution. The cardiac rhythm had been normal before the glucose bolus was given, but sinus arrest with junctional or idioventricular escape rhythm developed at the end of bolus administration, immediately followed by ventricular fibrillation (Figure 1). The patient was discharged 2 weeks later without any sequelae.Electrocardiographic changes are not usually seen until serum potassium exceeds 6.0–6.5 mmol/l. Disappearance of the P wave is usually seen when serum potassium exceeds 8 mmol/l [1]. We were surprised, however, to find changes in the absence of any increase in serum potassium. There was neither hyponatremia nor hypocalcemia, both of which increase sensitivity to hyperkalemia [2,3]. Even if serum potassium was normal, we think it possible there could have been local hyperkalemia, which led to sinus arrest and then to ventricular fibrillation. The mechanism of this hyperkalemia, we postulate, is that the high potassium concentration (1,074 mmol/l) in the deadspace of the tubing was flushed by the glucose, corresponding to a 11 mEq intravenous bolus of K+.The present case highlights a dangerous aspect of using concentrated solutions for K+ therapy. Although an infusion rate of 17 mEq/hour is usually considered safe, in the particular situation here, with a central venous catheter in an intrathoracic position, flushing the catheter created a bolus injection. Theoretically, such a poorly mixed bolus can cause dangerous concentrations in