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A web-based normative calculator for the uniform data set (UDS) neuropsychological test battery

DOI: 10.1186/alzrt94

Keywords: Alzheimer's disease, cognitive aging, MCI, memory, norms

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Abstract:

Data from 3,268 clinically cognitively-normal older UDS subjects from a cohort reported by Weintraub and colleagues (2009) were included. For all neuropsychological tests, z-scores were estimated by subtracting the raw score from the predicted mean and then dividing this difference score by the root mean squared error term (RMSE) for a given linear regression model.For each neuropsychological test, an estimated z-score was calculated for any raw score based on five different models that adjust for the demographic predictors of SEX, AGE and EDUCATION, either concurrently, individually or without covariates. The interactive online calculator allows the entry of a raw score and provides five corresponding estimated z-scores based on predictions from each corresponding linear regression model. The calculator produces percentile ranks and graphical output.An interactive, regression-based, normative score online calculator was created to serve as an additional resource for UDS clinical researchers, especially in guiding interpretation of individual performances that appear to fall in borderline realms and may be of particular utility for operationalizing subtle cognitive impairment present according to the newly proposed criteria for Stage 3 preclinical Alzheimer's disease.The Uniform Data Set (UDS) neuropsychological test battery is administered to research participants at all contributing Alzheimer's Disease Centers (ADCs) and Alzheimer's Disease Research Centers (ADRCs) [1]. However, because the subjects are not reflective of the national population and the tests within the UDS battery were modified for pragmatic use, reliable normative data are not available for the battery. Weintraub and colleagues [2] provided descriptive information from initial neuropsychological data of over 3,000 clinically cognitively normal, older adults and developed linear regression models to estimate the impact of age, sex, and education on test performance. The report by Weintraub et al.

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