Aspects of statin prescribing in Norwegian counties with high, average and low statin consumption – an individual-level prescription database study

Data were retrieved from The Norwegian Prescription Database. We included individuals from counties with high, average, and low statin consumption, who had at least one statin prescription dispensed during 2004 (N = 40 143).1-year prevalence, prescribed daily dose (PDD), statin of choice, and continuity of therapy assessed by mean number of tablets per day.The high-consumption county had higher prevalence of statin use in all age groups.Atorvastatin and simvastatin were dispensed in 79–87% of all statin users, and the proportion was significantly higher in the high-consumption county.The estimated PDDs were higher than the DDDs, up to twice the DDD for atorvastatin. The high-consumption county had the highest PDD for simvastatin (25.9 mg) and atorvastatin (21.9 mg), and more users received tablets in the upper range of available strengths. Continuity of therapy was similar in the three counties.Although differences in age-distribution seems to be an important source of variation in statin consumption, it cannot account for the total variation between counties in Norway. Variations in prevalences of use, and treatment intensity in terms of PDD and choice of statin also affect the total consumption. The results in this study seems to correspond to previous findings of more frequent statin use in primary prevention, and more statin users achieving lipid goal in the highest consuming county.During the last decade clinical data on the benefits of statins in the prevention of cardiovascular disease have accumulated [1]. Statin consumption, measured as defined daily doses (DDDs) per 1000 inhabitants per day, has increased remarkably in Norway, and is high compared with other European countries [2,3]. However, there are large and persistent regional differences in statin consumption in Norway [3]. In 2004, the top-consumption county, Hedmark, had a sales volume that was twice the level in the low-consumption county, Troms, and 40% higher than the neighbouring county, Opplan