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Neural Tube Defects – From Origin to Treatment

DOI: 10.1186/1743-8454-3-6

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Abstract:

The book is divided into three sections: Basic Principles, Treatment and Education, and Public Health Issues.The first section, Basic Principles, is further subdivided into four subsections, the first of which contains a group of papers, which are essential reading for anyone who wants or needs to update their knowledge of the embryology of neural tube development and the underlying biomolecular mechanisms. This is not easy reading but essential if one is to understand how and why things go wrong when spina bifida occurs. The second subsection deals with a variety of clinical features of neural tube defects. This subsection also includes papers concerned with the classification of the various manifestations of neural tube defects. Of particular interest are the myriads of syndromes that include spina bifida amongst their abnormalities. Do these conditions give a clue to the genetic defects in cases where spina bifida is the only abnormality? That is a hope not yet realised. Papers in the third subsection dedicated to the epidemiology of neural tube defects give a realistic view of the difficulties of collecting meaningful data and the strength and weaknesses of statistics based on these data. It is no longer a mystery why there is no consensus of opinion about whether the conception rate of spina bifida is increasing, staying the same or decreasing or indeed why the reported incidence of spina bifida in any particular country varies from one author to another. The last subsection deals with the genetics of neural tube defects. These chapters also do not make for easy reading for those not conversant with the names of the multitude of genes involved, but as future developments of the understanding, treatment and management of spina bifida are likely to come in this field of study, it is essential that all make themselves familiar with this work.The second section is concerned with the Treatment and Education of patients with spina bifida. In this section the whole li

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