Review of "The Blood-Cerebrospinal Fluid Barrier" by Wei Zheng and Adam Chodobski (editors)

The blood-cerebrospinal fluid barrier functions together with the blood-brain barrier and the meninges, to control the internal environment of the brain. Sited at the choroid plexus epithelium, it secretes the cerebrospinal fluid (CSF), which circulates through the ventricles and around the outside of the brain and spinal cord. Originally assumed to pass an ultra filtrate of plasma into the brain ventricles, the choroid plexus was subsequently shown to secrete a homeostatically controlled electrolyte solution, the CSF [1]. In the last twenty years the choroidal epithelium has emerged as a complex organ with many additional functions that include neuroendocrine signaling, neuroimmune and neuroinflammatory responses, drug and toxin metabolism and transport. There is an increasing awareness that improved knowledge of the role of the choroid plexus in brain function has the potential to open new avenues for the treatment and prevention of neurological disorders.There has been a requirement for a comprehensive review on the choroid plexus and blood-CSF barrier for a number of years [2]. This multi-author book edited by Wei Zheng and Adam Chodobski has 24 chapters and 51 contributors. The chapters have a consistent style and each one has a complete reference list. The book fulfills an important need for research scientists in the field of choroid plexus and CSF and as a reference book for neuroscientists, clinicians and toxicologists. Section 1 is devoted to choroid plexus development and morphology, section 2 to barrier physiology and molecular biology, section 3 to the barrier in disease states and section 4 to in vivo and in vitro models of the barrier. Many topics are covered in this book and it is possible to select only a few for mention as being of particular interest. The proteins and lipids that make up the intercellular tight junctions are being elucidated at the molecular level, but how permeability is regulated awaits further investigation. The physiological r