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Using respiratory rate and thoracic movement to assess respiratory insufficiency in amyotrophic lateral sclerosis: a preliminary study

DOI: 10.1186/1472-684x-11-26

Keywords: Amyotrophic lateral sclerosis, Hypoventilation, Non-invasive ventilation

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Abstract:

We measured the respiratory rate and thoracic movement, performed respiratory function tests and blood gas analysis, and recorded subjective hypoventilation symptoms in 42 ALS patients over a 7-year period. We recommended NIV if the patient presented with hypoventilation matching the current guidelines. We divided patients retrospectively into two groups: those to whom NIV was recommended within 6 months of the diagnosis (Group 1) and those to whom NIV was recommended 6 months after the diagnosis (Group 2). We used the Mann Whitney U test for comparisons between the two groups.The mean partial pressure of arterial carbon dioxide in the morning in Group 1 was 6.3 (95% confidence interval 5.6–6.9) kPa and in Group 2 5.3 (5.0–5.6) kPa (p = 0.007). The mean respiratory rate at the time of diagnosis in Group 1 was 21 (18–24) breaths per minute and 16 (14–18) breaths per minute in Group 2 (p = 0.005). The mean thoracic movement was 2.9 (2.2–3.6) cm in Group 1 and 4.0 (3.4–4.8) cm in Group 2 (p = 0.01). We observed no other differences between the groups.Patients who received NIV within six months of the diagnosis of ALS had higher respiratory rates and smaller thoracic movement compared with patients who received NIV later. Further studies with larger numbers of patients are needed to establish if these measurements can be used as a marker of hypoventilation in ALS.Amyotrophic lateral sclerosis (ALS) is a form of degenerative motor neuron disease of unknown etiology. The disease is characterized by progressive muscle weakness and atrophy throughout the body [1-3]. The prevalence is 4–8 in 100 000 and the annual incidence is 1–2 in 100 000 [4]. Prognosis is poor with a median survival from the onset of symptoms of 2–4 years [5,6]. Despite extensive effort, no curative treatment is available and riluzole (a tetrodotoxin-sensitive sodium channel blocker) is the only drug that can slow the progression of the disease [7,8]. Therefore, treatment following the diagnosis is palli

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