Separation and Determination of Nycodenz and Its Impurities by Capillary Electrophoresis
毛细管电泳分离测定碘海醇及其杂质

Separation and determination of nycodenz (a new radiography reagent) and its impurities by capillary electrophoresis was investigated. Since the analytes were polyols, Na 2B 4O 7 H 3BO 3 was chosen as the buffer system. The analytes were negatively charged by complexing with borate. Then cetyltrimethyl ammonium bromide was used to reverse electroosmotic mobility in order to shorten the analysis time. 2 Propanol was added to optimize the separation further. Acceptable results of linearity, precision of corrected peak area and migration time were obtained. The RSD(n=6) of corrected peak area and migration time were 0.73% and 1.4% respectively. The results obtained by CE were directly compared to those obtained by high performance liquid chromatography.