Determination of Captopril in Tablets by Gas Chromatography(GC)
气相色谱法测定卡托普利含量

A GC method for determination of captopril in tablets was developed. The sample was esterified to improve its sensitivity. The conditions for determination were: 2% OV-17 on 80-100 mesh Chromosorb W AW-DMCS packed in a 2 m x 3 mm i.d. column operated at 190 degrees C. Both FID detector and injector port at 220 degrees C. Octadecane was used as internal standard. The response was linear between 0.2 g/L and 1 g/L. This method is proved to be highly sensitive, good reproducible and satisfactory.