Quantitative Determinations of Glycyrrhizic Acid, Glycyrrhetinic Acid,Morphine and Sodium Benzoate in Compound LiquoriceTablets by Capillary Zone Electrophoresis
毛细管区带电泳法测定复方甘草片中的甘草酸、甘草次酸、吗啡和苯甲酸钠

Capillary zone electrophoresis (CZE) was used to quantitatively determine the contents of glycyrrhizic acid, glycyrrhetinic acid, morphine and sodium benzoate in compound liquorice tablets The detection wavelength was 228 nm and the applied voltage was 14 kV. Borax solution of 50 mmol/L was used as the background electrolyte and hydrochlorothiazide as the internal standard There were all good linear relationships between the concentrations and the relative areas of glycyrrhizic acid, glycyrrhetinic acid, morphine and sodium benzoate Their average recoveries were 98 2%,97 3%,97 1% and 97 5%, respectively The method is simple, rapid and accurate