Association of inflammation with atrial fibrillation in hyperthyroidism
Association of Inflammation with Atrial Fibrillation in Hyperthyroidism

Objective: The aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism. Methods: A total of 65 patients with newly-diagnosed hyperthyroidism, 35 of whom in sinus rhythm and 30 of whom in AF and 35 age- and gender-matched patients in control group were included. Factors associated with the development of AF were evaluated with multivariate regression analysis. Results: Factors associated with AF in multivariate analysis included high sensitivity C reactive protein (odds ratio, 11.19; 95% confidence interval, 1.80 to 69.53; p = 0.003), Free T4 (odds ratio, 8.76; 95% confidence interval, 2.09 to 36.7; p = 0.003) and left atrial diameter (odds ratio, 1.25; 95% confidence interval, 1.06 to 1.47; p = 0.008). Conclusion: Present study suggests that High sensitivity C reactive protein, an indicator of inflammation, Free T4 and left atrial diameter are associated with development AF in patients with hyperthyroidism.