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科学通报(英文版) 2010
Bioinformatics study indicates possible microRNA-regulated pathways in the differentiation of breast cancer
Keywords: microRNA,breast cancer,TGF-βpathway,histological grade Abstract: microRNAs (miRNAs) have been reported to be associated with the pathogenesis and progression of breast cancer.However,little is known about the pathways through which miRNAs regulate these processes,e.g.,the interaction between miRNAs and their target genes with regard to different pathological status of breast cancer,such as histological grades.This study investigated the possible roles of miRNAs in the differentiation of histological grades of breast cancer with a computational approach.Based on a microar...
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