Progress and perspective of the kinetochore-associated motor proteins

The kinetochore is structurally composed offour layers. We know that three microtubule-based motorproteins such as CENP-E, dynein, and MCAK are located at the outmost region of the kinetochore. Experimentation ofthese motor functions betters our understanding of mitotic regulation, and chromosome movements in particular.With real-time studies of chromosome movements in livecells, we hope to illustrate the molecular mechanisms under-lying mitotic regulation.