The use of complementary and alternative medicines including dietary supplements, herbals and special diets to prevent or treat disease continues to be popular. The following paper provides a description of an alternative dietary approach to the self-management and treatment of cancer, the Bill Henderson Protocol (BHP). This diet encourages daily intake of raw foods, a combination of cottage cheese and flaxseed oil and a number of supplements. Some foods and food groups are restricted (e.g., gluten, meat, dairy). Early background theory that contributed to the protocol’s development is presented as is a summary of relevant evidence concerning the anti-cancer fighting properties of the individual components. Supplement intake is considered in relation to daily recommended intakes. Challenges and risks to protocol adherence are discussed. As with many complementary and alternative interventions, clear evidence of this dietary protocol’s safety and efficacy is lacking. Consumers of this protocol may require guidance on the ability of this protocol to meet their individual nutritional needs.
References
[1]
Henderson, B. Cancer-Free: Your Guide to Gentle Non-Toxic Healing, 2nd ed.; Booklocker.com: Bangor, ME, USA, 2007.
[2]
Evans, M.; Shaw, A.; Thompson, E.A.; Falk, S.; Turton, P.; Thompson, T.; Sharp, D. Decisions to use complementary and alternative medicine (CAM) by male cancer patients: information？seeking roles and types of evidence used. BMC Complement. Altern. Med.？2007, 7, 25, doi:10.1186/1472-6882-7-25. 17683580
[3]
Montazeri, A.; Sajadian, A.; Ebrahimi, M.; Haghighat, S.; Harirchi, I. Factors predicting the use of complementary and alternative therapies among cancer patients in Iran. Eur. J. Cancer Care (Engl.)？2007, 16, 144–149, doi:10.1111/j.1365-2354.2006.00722.x.
[4]
Henderson, B. Beating Cancer Gently Home Page. 2010. Available online: http://www.beating-cancer-gently.com (accessed on 21 June 2010).
[5]
Kristoffersen, A.E.; Fonnebo, V.; Norheim, A.J. Do cancer patients with a poor prognosis use complementary and alternative medicine more often than others? J. Altern. Complement. Med.？2009, 15, 35–40, doi:10.1089/acm.2008.0262. 19769474
[6]
American Cancer Society. Questionable methods of cancer management: “nutritional” therapies. CA Cancer J. Clin.？1993, 43, 309–319, doi:10.3322/canjclin.43.5.309. 8364770
[7]
Institute of Medicine. Daily Recommended Intakes. 2005. Available online: http://books.nap.edu/openbook.php?record_id=10490&page=1320 (accessed on 22 June 2010).
[8]
Henderson, B. Buy the Book. Beating Cancer Gently Web site, 2010. Available online: http://www.beating-cancer-gently.com/buybook.html (accessed on 21 June 2010).
[9]
Page, S.; Mannion, C.; Bell, L.H.; Verhoef, M.J. The Bill Henderson Protocol: Consumer perspective and practices on an alternative dietary intervention for cancer treatment and cure. Complement. Ther. Med.？2010. unpublished work.
[10]
Budwig, J. Remarks on Homann and Otto’s, Treatment of cancer patients with positive-pressure ether. Hippokrates？1953, 24, 600–601. 13128655
[11]
Budwig, J. Cytostatic or cytodynamic control of cancer? Hippokrates？1956, 27, 605–612. 13376028
[12]
Budwig, J. Photo-elements of life as an anti-carcinoma factor, successful as a preventive and in the progressive state of the illness. Minerva Ginecol.？1971, 23, 115–117. 5579726
[13]
Budwig, J. Cancer: The Problem and the Solution; Nexus: Kernen, Germany, 2005.
[14]
Hans Krebs. Nobel Prize Web site, 2010. Available online: http://nobelprize.org/nobel_prizes/medicine/laureates/1953/index.html (accessed on 26 October 2010).
[15]
Otto Warburg. Nobel Prize Web site, 2009. Available online: http://nobelprize.org/nobel_prizes/medicine/laureates/1931/warburg-bio.html (accessed on 15 September 2009).
[16]
Otto Warburg—Yellow enzyme. Encyclopedia Britannica, 2009. Available online: http://www.britannica.com/EBchecked/topic/635734/Otto-Warburg#ref=ref139725 (accessed on 15 September 2009).
[17]
Warburg, O. The Chemical Constitution of Respiration Ferment. Science？1928, 68, 437–443, doi:10.1126/science.68.1767.437. 17782077
[18]
Warburg, O. On respiratory impairment in cancer cells. Science？1956, 124, 269–270. 13351639
[19]
Warburg, O. On the origin of cancer cells. Science？1956, 123, 309–314, doi:10.1126/science.123.3191.309. 13298683
[20]
Budwig, J. Flax Oil as a True Aid against Arthritis, Heart Infarction, Cancer and Other Diseases; Apple Publishing Company: Vancouver, BC, Canada, 1994.
[21]
Kaufmann, H.; Budwig, J.; Duddek, E. Die Papier-Chromatographie auf dem Fettgebiet VI: Anwendung auf Seifen. Fette und Seifen？1951, 53, 285–288, doi:10.1002/lipi.19510530511.
[22]
Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet IX: Anwendung auf Lackrohstoffe. Fette und Seifen？1951, 53, 408–412, doi:10.1002/lipi.19510530707.
[23]
Kaufmann, H.; Budwig, J.; Szakall, A. Die Papier-Chromatographie auf dem Fettgebiet VIII: Der Lipoid-Nachschub in der lebenden menschlichen Haut und seine papier-chromatographische Bestimmung. Fette und Seifen？1951, 53, 406–408, doi:10.1002/lipi.19510530706.
[24]
Kaufmann, H.; Budwig, J. Zur Biologie der Fette V: Die Papier-Chromatographie der Blutlipoide, Geschwulstproblem und Fettforschung. Fette und Seifen？1952, 54, 156–165, doi:10.1002/lipi.19520540310.
[25]
Kaufmann, H.; Budwig, J.; Schmidt, C. Die Papier-Chromatographie auf dem Fettgebiet XI: Nachweis und Trennung von Konjuen-Fetts？uren. Fette und Seifen？1952, 54, 10–12, doi:10.1002/lipi.19520540105.
[26]
Kaufmann, H.; Budwig, J.; Schmidt, C. Die Papier-Chromatographie auf dem Fettgebiet XII: Nachweis und Trennung von Konjuen-Fet s？uren, 2. Teil. Fette und Seifen？1952, 54, 73–76, doi:10.1002/lipi.19520540204.
[27]
Kaufmann, H.; Budwig, J. Der ？Schaumtest？ in der Papier-Chromatographie. Fette und Seifen？1950, 52, 555–556, doi:10.1002/lipi.19500520909.
[28]
Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet IV: Die Radiometrie der ？ls？ure. Fette und Seifen？1951, 53, 69–73, doi:10.1002/lipi.19510530203.
[29]
Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet VII: Nachweis und Trennung von Fetts？uren. Fette und Seifen？1951, 53, 390–399, doi:10.1002/lipi.19510530704.
[30]
Kaufmann, H.; Budwig, J. Dei Papier-Chromatographie auf dem Fettgebiet V: Die radiometrische Jodzahl der Fette. Fette und Seifen？1951, 53, 253–259, doi:10.1002/lipi.19510530502.
[31]
Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet XIV: Untersuchung von ？Poly-？len？. Fette und Seifen？1952, 54, 348–356, doi:10.1002/lipi.19520540607.
[32]
Kaufmann, H.; Budwig, J. Die Papier-Chromatographie auf dem Fettgebiet X: Fluoreszenz-Farben als Indikatoren bei der papyrographischen Analyse von Fetts？uren und Fetten. Fette und Seifen？1952, 54, 7–10, doi:10.1002/lipi.19520540104.
[33]
Gonzalez, C.A.; Riboli, E. Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur. J. Cancer？2010, 46, 2555–2562, doi:10.1016/j.ejca.2010.07.025. 20843485
Flaxseed oil. Natural Standard Web site, 2010. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/aux1-flaxseed.asp&patientVersion=/monographs/herbssupplements/patient-flaxseed.asp (accessed on 21 June 2010).
[36]
Marnett, L.J. Oxyradicals and DNA damage. Carcinogenesis？2000, 21, 361–370, doi:10.1093/carcin/21.3.361. 10688856
[37]
Valko, M.; Izakovic, M.; Mazur, M.; Rhodes, C.J.; Telser, J. Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell. Biochem.？2004, 266, 37–56, doi:10.1023/B:MCBI.0000049134.69131.89. 15646026
[38]
Peter Mitchell. Nobel Prize Web site, 2010. Available online: http://nobelprize.org/nobel_prizes/chemistry/laureates/1978/ (accessed on 26 October 2010).
[39]
Colombo, M.L. An update on vitamin E, tocopherol and tocotrienol—perspectives. Molecules？2010, 15, 2103–2113, doi:10.3390/molecules15042103. 20428030
[40]
Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. Report of the World Cancer Research Fund and American Institute for Cancer Research. Chapter 2. The Cancer Process. 2007. Available online: http://www.dietandcancerreport.org/downloads/chapters/chapter_02.pdf (accessed on 28 June 2010).
[41]
Mahan, L.K.; Escott-Stump, S. Krause’s Food, Nutrition & Diet Therapy, 11th ed.; Saunders: Philadelphia, PA, USA, 2004.
[42]
Roberts, D.C. Quick weight loss: Sorting fad from fact. Med. J. Aust.？2001, 175, 637–640. 11837873
[43]
Groff, J.; Gropper, S. Advanced Nutrition and Human Metabolism, 3rd ed.; Wadsworth: Belmont, CA, USA, 2000; pp. 133–135.
[44]
Brody, T. Nutritional Biochemistry, 2nd ed.; Academic Press: San Diego, CA, USA, 1999.
[45]
Olson, R.E. Discovery of the lipoproteins, their role in fat transport and their significance as risk factors. J. Nutr.？1998, 128, 439S–443S. 9478044
[46]
Goldstein, J.L.; Brown, M.S. The LDL receptor. Arterioscler. Thromb. Vasc. Biol.？2009, 29, 431–438, doi:10.1161/ATVBAHA.108.179564. 19299327
[47]
Chajes, V.; Thiebaut, A.C.M.; Rotival, M.; Gauthier, E.; Maillard, V.; Boutron-Ruault, M.C.; Joulin, V.; Lenoir, G.M.; Clavel-Chapelon, F. Association between Serum trans-Monounsaturated Fatty Acids and Breast Cancer Risk in the E3N-EPIC Study. Am. J. Epidemiol.？2008, 167, 1312–1320, doi:10.1093/aje/kwn069. 18390841
[48]
Lopez-Garcia, E.; Schulze, M.B.; Meigs, J.B.; Manson, J.E.; Rifai, N.; Stampfer, M.J.; Willett, W.C.; Hu, F.B. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J. Nutr.？2005, 135, 562–566. 15735094
[49]
Remig, V.; Franklin, B.; Margolis, S.; Kostas, G.; Nece, T.; Street, J.C. Trans fats in America: A review of their use, consumption, health implications, and regulation. J. Am. Diet. Assoc.？2010, 110, 585–592, doi:10.1016/j.jada.2009.12.024. 20338284
[50]
Ratnayake, W.M.; L’Abbe, M.R.; Farnworth, S.; Dumais, L.; Gagnon, C.; Lampi, B.; Casey, V.; Mohottalage, D.; Rondeau, I.; Underhill, L.; et al. Trans fatty acids: Current contents in Canadian foods and estimated intake levels for the Canadian population. J. AOAC Int.？2009, 92, 1258–1276. 19916364
[51]
Michels, K.B.; Willett, W.C. The Women’s Health Initiative Randomized Controlled Dietary Modification Trial: A post-mortem. Breast Cancer Res. Treat.？2009, 114, 1–6, doi:10.1007/s10549-008-9972-x. 18373274
[52]
Mason, J.K.; Chen, J.; Thompson, L.U. Flaxseed oil-trastuzumab interaction in breast cancer. Food Chem. Toxicol.？2010, 48, 2223–2226, doi:10.1016/j.fct.2010.05.052. 20580760
[53]
Saggar, J.K.; Chen, J.; Corey, P.; Thompson, L.U. Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor？signaling pathways. Mol. Nutr. Food Res.？2010, 54, 415–425, doi:10.1002/mnfr.200900068. 19904759
[54]
Natural Standard Beta-glucan. Natural Standard Web site, 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/betaglucan.asp&patientVersion=/monographs/herbssupplements/patient-betaglucan.asp (accessed on 12 October 2010).
[55]
Akramiene, D.; Kondrotas, A.; Didziapetriene, J.; Kevelaitis, E. Effects of beta-glucans on the immune system. Medicina (Kaunas)？2007, 43, 597–606. 17895634
Chan, G.C.; Chan, W.K.; Sze, D.M. The effects of beta-glucan on human immune and cancer cells. J. Hematol. Oncol.？2009, 2, 25, doi:10.1186/1756-8722-2-25. 19515245
[58]
Chen, J.; Seviour, R. Medicinal importance of fungal beta-(1→3), (1→6)-glucans. Mycol. Res.？2007, 111, 635–652, doi:10.1016/j.mycres.2007.02.011. 17590323
[59]
Fujimoto, K.; Tomonaga, M.; Goto, S. A case of recurrent ovarian cancer successfully treated with adoptive immunotherapy and lentinan. Anticancer Res.？2006, 26, 4015–4018. 17195451
[60]
Demir, G.; Klein, H.O.; Mandel-Molinas, N.; Tuzuner, N. Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int. Immunopharmacol.？2007, 7, 113–116, doi:10.1016/j.intimp.2006.08.011. 17161824
[61]
Ferrone, M.; Raimondo, M.; Scolapio, J.S. Pancreatic enzyme pharmacotherapy. Pharmacotherapy？2007, 27, 910–920, doi:10.1592/phco.27.6.910. 17542772
[62]
Arnett, T.R. Extracellular pH regulates bone cell function. J. Nutr.？2008, 138, 415S–418S. 18203913
[63]
Fenton, T.R.; Eliasziw, M.; Lyon, A.W.; Tough, S.C.; Hanley, D.A. Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis. Am. J. Clin. Nutr.？2008, 88, 1159–1166. 18842807
[64]
Fenton, T.R.; Eliasziw, M.; Tough, S.C.; Lyon, A.W.; Brown, J.P.; Hanley, D.A. Low urine pH and acid excretion do not predict bone fractures or the loss of bone mineral density: a prospective cohort study. BMC Musculoskelet. Disord.？2010, 11, 88, doi:10.1186/1471-2474-11-88. 20459740
[65]
Konig, D.; Muser, K.; Dickhuth, H.H.; Berg, A.; Deibert, P. Effect of a supplement rich in alkaline minerals on acid-base balance in humans. Nutr. J.？2009, 8, 23, doi:10.1186/1475-2891-8-23. 19515242
[66]
Bar-Sela, G.; Tsalic, M.; Fried, G.; Goldberg, H. Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: A pilot study. Nutr. Cancer？2007, 58, 43–48, doi:10.1080/01635580701308083. 17571966
[67]
Rath, M.; Pauling, L. Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs. J. Orthomol. Med.？1992, 7, 17–23.
[68]
Rath, M. Reducing the Risk for Cardiovascular Disease with Nutritional Supplements. J. Orthomol. Med.？1992, 7, 153–162.
[69]
Rath Institute Research. Dr. Mathias Rath Institute Web site, 2009. Available online: http://www4.dr-rath-foundation.org/pdf-files/cancerresearch.pdf (accessed on 23 June 2010).
[70]
Demeule, M.; Brossard, M.; Page, M.; Gingras, D.; Beliveau, R. Matrix metalloproteinase inhibition by green tea catechins. Biochim. Biophys. Acta？2000, 1478, 51–60, doi:10.1016/S0167-4838(00)00009-1. 10719174
[71]
Ivanov, V.; Ivanova, S.; Roomi, M.W.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Naturally produced extracellular matrix inhibits growth rate and invasiveness of human osteosarcoma cancer cells. Med. Oncol.？2007, 24, 209–217, doi:10.1007/BF02698042. 17848746
[72]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Anti-tumor effect of ascorbic acid, lysine, proline, arginine, and epigallocatechin gallate on prostate cancer cell lines PC-3, LNCaP, and DU145. Res. Commun. Mol. Pathol. Pharmacol.？2004, 115–116, 251–264. 17564322
[73]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Anti-angiogenic effects of a nutrient mixture on human umbilical vein endothelial cells. Oncol. Rep.？2005, 14, 1399–1404. 16273231
[74]
Roomi, M.W.; Roomi, N.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis. Oncol. Rep.？2005, 14, 807–815. 16142336
[75]
Roomi, M.W.; Roomi, N.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Modulation of N-methyl-N-nitrosourea induced mammary tumors in Sprague-Dawley rats by combination of lysine, proline, arginine, ascorbic acid and green tea extract. Breast Cancer Res.？2005, 7, R291–R295, doi:10.1186/bcr989. 15987424
[76]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vitro and in vivo antitumorigenic activity of a mixture of lysine, proline, ascorbic acid, and green tea extract on human breast cancer lines MDA-MB-231 and MCF-7. Med. Oncol.？2005, 22, 129–138, doi:10.1385/MO:22:2:129. 15965275
[77]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Antitumor effect of a combination of lysine, proline, arginine, ascorbic acid, and green tea extract on pancreatic cancer cell line MIA PaCa-2. Int. J. Gastrointest. Cancer？2005, 35, 97–102, doi:10.1385/IJGC:35:2:097. 15879623
[78]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human prostate cancer PC-3 xenografts in nude mice: evaluation of tumor growth and immunohistochemistry. In Vivo？2005, 19, 179–183. 15796171
[79]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human colon cancer cell HCT 116 xenografts in nude mice: Evaluation of tumor growth and immunohistochemistry. Oncol. Rep.？2005, 13, 421–425. 15706410
[80]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Antitumor effect of nutrient synergy on human osteosarcoma cells U-2OS, MNNG-HOS and Ewing’s sarcoma SK–ES.1. Oncol. Rep.？2005, 13, 253–257. 15643507
[81]
Roomi, M.W.; Roomi, N.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of pulmonary metastasis of melanoma b16fo cells in C57BL/6 mice by a nutrient mixture consisting of ascorbic Acid, lysine, proline, arginine, and green tea extract. Exp. Lung Res.？2006, 32, 517–530, doi:10.1080/01902140601098552. 17169857
[82]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry. Med. Oncol.？2006, 23, 411–418, doi:10.1385/MO:23:3:411. 17018899
[83]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Anticancer effect of lysine, proline, arginine, ascorbic acid and green tea extract on human renal adenocarcinoma line 786-0. Oncol. Rep.？2006, 16, 943–947. 17016575
[84]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Suppression of human cervical cancer cell lines Hela and DoTc2 4510 by a mixture of lysine, proline, ascorbic acid, and green tea extract. Int. J. Gynecol. Cancer？2006, 16, 1241–1247, doi:10.1111/j.1525-1438.2006.00545.x. 16803512
[85]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of malignant mesothelioma cell matrix metalloproteinase production and invasion by a novel nutrient mixture. Exp. Lung Res.？2006, 32, 69–79, doi:10.1080/01902140600710488. 16754473
[86]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24. Int. J. Urol.？2006, 13, 415–419, doi:10.1111/j.1442-2042.2006.01309.x. 16734861
[87]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on human fibrosarcoma cells HT-1080. Med. Oncol.？2006, 23, 105–111, doi:10.1385/MO:23:1:105. 16645235
[88]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of matrix metalloproteinase-2 secretion and invasion by human ovarian cancer cell line SK-OV-3 with lysine, proline, arginine, ascorbic acid and green tea extract. J. Obstet. Gynaecol. Res.？2006, 32, 148–154, doi:10.1111/j.1447-0756.2006.00389.x. 16594917
[89]
Roomi, M.W.; Ivanov, V.; Netke, S.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline and green tea extract on human melanoma cell line A2058. In Vivo？2006, 20, 25–32. 16433024
[90]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of cell invasion and MMP production by a nutrient mixture in malignant liposarcoma cell line SW-872. Med. Oncol.？2007, 24, 394–401, doi:10.1007/s12032-007-0022-z. 17917088
[91]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibition of glioma cell line A-172 MMP activity and cell invasion in vitro by a nutrient mixture. Med. Oncol.？2007, 24, 231–238, doi:10.1007/BF02698045. 17848749
[92]
Roomi, M.W.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibitory effects of a nutrient mixture on human testicular cancer cell line NT 2/DT matrigel invasion and MMP activity. Med. Oncol.？2007, 24, 183–188, doi:10.1007/BF02698038. 17848742
[93]
Roomi, M.W.; Roomi, N.W.; Kalinovsky, T.; Ivanov, V.; Rath, M.; Niedzwiecki, A. Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture. Med. Oncol.？2008, 25, 333–340, doi:10.1007/s12032-008-9041-7. 18204975
[94]
Roomi, M.W.; Bhanap, B.A.; Roomi, N.W.; Rath, M.; Niedzwiecki, A. Antineoplastic effects of nutrient mixture on raji and jurkat t cells: the two highly aggressive non hodgkin’s lymphoma cell lines. Exp. Oncol.？2009, 31, 149–155. 19783966
[95]
Roomi, M.W.; Roomi, N.W.; Kalinovsky, T.; Rath, M.; Niedzwiecki, A. Marked inhibition of growth and invasive parameters of head and neck squamous carcinoma FaDu by a nutrient mixture. Integr. Cancer Ther.？2009, 8, 168–176, doi:10.1177/1534735408334632. 19679626
[96]
Waheed, R.M.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. In vivo and in vitro antitumor effect of a unique nutrient mixture on lung cancer cell line A-549. Exp. Lung Res.？2006, 32, 441–453, doi:10.1080/01902140601047658. 17162651
[97]
Rundhaug, J.E. Matrix Metalloproteinases, Angiogenesis, and Cancer: Commentary re: A. C. Lockhart et al., Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor. Clin. Cancer Res., 9: 00-00, 2003. Clin. Cancer Res.？2003, 9, 551–554. 12576417
[98]
Lode, H.N.; Huebener, N.; Strandsby, A.; Gaedicke, G. Nutrient mixture including vitamin C, L-lysine, L-proline, and epigallocatechin is ineffective against tumor growth and metastasis in a syngeneic neuroblastoma model. Pediatr. Blood Cancer？2008, 50, 284–288, doi:10.1002/pbc.21172. 17366537
[99]
Tolerable Upper Intake Levels. Institute of Medicine. 2005. Available online: http://books.nap.edu/openbook.php?record_id=10490&page=1326 (accessed on 22 June 2010).
[100]
Natural Standard Home. 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/index.asp (accessed on 9 October 2009).
[101]
Natural Standard Online Database. 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/index.asp?file=/html/about.html (accessed on 9 October 2009).
[102]
Natural Standard grading scale. 2009. Available online: http://www.naturalstandard.com.ezproxy.lib.ucalgary.ca/monographs/flashcards/flashcard-spirulina.asp (accessed on 9 October 2009).
[103]
Peirce, A. The American Pharmaceutical Association Practical Guide to Natural Medicines; Stonesong Press Book: New York, NY, USA, 1999.
[104]
Lee, J.E.; Mannisto, S.; Spiegelman, D.; Hunter, D.J.; Bernstein, L.; van den Brandt, P.A.; Buring, J.E.; Cho, E.; English, D.R.; Flood, A.; et al. Intakes of fruit, vegetables, and carotenoids and renal cell cancer risk: A pooled analysis of 13 prospective studies. Cancer Epidemiol. Biomarkers Prev.？2009, 18, 1730–1739, doi:10.1158/1055-9965.EPI-09-0045. 19505906
[105]
Lin, J.; Kamat, A.; Gu, J.; Chen, M.; Dinney, C.P.; Forman, M.R.; Wu, X. Dietary intake of vegetables and fruits and the modification effects of GSTM1 and NAT2 genotypes on bladder cancer risk. Cancer Epidemiol. Biomarkers Prev.？2009, 18, 2090–2097, doi:10.1158/1055-9965.EPI-08-1174. 19549811
[106]
Satia, J.A.; Tseng, M.; Galanko, J.A.; Martin, C.; Sandler, R.S. Dietary patterns and colon cancer risk in Whites and African Americans in the North Carolina Colon Cancer Study. Nutr. Cancer？2009, 61, 179–193, doi:10.1080/01635580802419806. 19235034
[107]
Van, H.L. Nutritional research: The power behind the fad-free diet. J. Am. Diet. Assoc.？2007, 107, 371, doi:10.1016/j.jada.2007.01.020. 17324649
[108]
De, S.E.; Boffetta, P.; Deneo-Pellegrini, H.; Ronco, A.L.; Aune, D.; Acosta, G.; Brennan, P.; Mendilaharsu, M.; Ferro, G. Meat intake, meat mutagens and risk of lung cancer in Uruguayan men. Cancer Causes Control？2009, 20, 1635–1643, doi:10.1007/s10552-009-9411-2. 19685149
[109]
Ferrucci, L.M.; Cross, A.J.; Graubard, B.I.; Brinton, L.A.; McCarty, C.A.; Ziegler, R.G.; Ma, X.; Mayne, S.T.; Sinha, R. Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Br. J. Cancer？2009, 101, 178–184, doi:10.1038/sj.bjc.6605118. 19513076
[110]
Taylor, V.H.; Misra, M.; Mukherjee, S.D. Is red meat intake a risk factor for breast cancer among premenopausal women? Breast Cancer Res Treat.？2009, 117, 1–8, doi:10.1007/s10549-009-0441-y.
[111]
Pala, V.; Krogh, V.; Berrino, F.; Sieri, S.; Grioni, S.; Tjonneland, A.; Olsen, A.; Jakobsen, M.U.; Overvad, K.; Clavel-Chapelon, F.; et al. Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am. J. Clin. Nutr.？2009, 90, 602–612, doi:10.3945/ajcn.2008.27173. 19491385
[112]
Ferrucci, L.M.; Sinha, R.; Graubard, B.I.; Mayne, S.T.; Ma, X.; Schatzkin, A.; Schoenfeld, P.S.; Cash, B.D.; Flood, A.; Cross, A.J. Dietary meat intake in relation to colorectal adenoma in asymptomatic women. Am. J. Gastroenterol.？2009, 104, 1231–1240, doi:10.1038/ajg.2009.102. 19367270
[113]
Pauwels, E.K.; Kairemo, K. Fatty acid facts, part II: role in the prevention of carcinogenesis, or, more fish on the dish? Drug News Perspect.？2008, 21, 504–510, doi:10.1358/dnp.2008.21.9.1290819. 19180268
[114]
Chavarro, J.E.; Stampfer, M.J.; Hall, M.N.; Sesso, H.D.; Ma, J. A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality. Am. J. Clin. Nutr.？2008, 88, 1297–1303. 18996866
[115]
Melnik, B.C. Milk—the promoter of chronic Western diseases. Med. Hypotheses？2009, 72, 631–639, doi:10.1016/j.mehy.2009.01.008. 19232475
[116]
Van der Pols, J.C.; Bain, C.; Gunnell, D.; Smith, G.D.; Frobisher, C.; Martin, R.M. Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort. Am. J. Clin. Nutr.？2007, 86, 1722–1729. 18065592
[117]
Huncharek, M.; Muscat, J.; Kupelnick, B. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr. Cancer？2009, 61, 47–69, doi:10.1080/01635580802395733. 19116875
[118]
Lee, S.A.; Shu, X.O.; Yang, G.; Li, H.; Gao, Y.T.; Zheng, W. Animal origin foods and colorectal cancer risk: A report from the Shanghai Women’s Health Study. Nutr. Cancer？2009, 61, 194–205, doi:10.1080/01635580802419780. 19235035
[119]
Lappe, J.M.; Travers-Gustafson, D.; Davies, K.M.; Recker, R.R.; Heaney, R.P. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am. J. Clin. Nutr.？2007, 85, 1586–1591. 17556697
[120]
Pilz, S.; Tomaschitz, A.; Obermayer-Pietsch, B.; Dobnig, H.; Pieber, T.R. Epidemiology of vitamin D insufficiency and cancer mortality. Anticancer Res.？2009, 29, 3699–3704. 19667167
[121]
Battais, F.; Richard, C.; Jacquenet, S.; Denery-Papini, S.; Moneret-Vautrin, D.A. Wheat grain allergies: An update on wheat allergens. Eur. Ann. Allergy Clin. Immunol.？2008, 40, 67–76. 19334370
Freeman, H.J. Adult celiac disease and its malignant complications. Gut Liver？2009, 3, 237–246, doi:10.5009/gnl.2009.3.4.237. 20431755
[124]
Jiao, L.; Flood, A.; Subar, A.F.; Hollenbeck, A.R.; Schatzkin, A.; Stolzenberg-Solomon, R. Glycemic index, carbohydrates, glycemic load, and the risk of pancreatic cancer in a prospective cohort study. Cancer Epidemiol. Biomarkers Prev.？2009, 18, 1144–1151, doi:10.1158/1055-9965.EPI-08-1135. 19336549
[125]
Polesel, J.; Talamini, R.; Negri, E.; Bosetti, C.; Boz, G.; Lucenteforte, E.; Franceschi, S.; Serraino, D.; La, V.C. Dietary habits and risk of pancreatic cancer: an Italian case-control study. Cancer Causes Control？2010, 21, 493–500, doi:10.1007/s10552-009-9480-2. 20091114
[126]
Mulholland, H.G.; Cantwell, M.M.; Anderson, L.A.; Johnston, B.T.; Watson, R.G.; Murphy, S.J.; Ferguson, H.R.; McGuigan, J.; Reynolds, J.V.; Comber, H.; Murray, L.J. Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Cancer Causes Control？2009, 20, 279–288, doi:10.1007/s10552-008-9242-6. 18839322
[127]
Lajous, M.; Boutron-Ruault, M.C.; Fabre, A.; Clavel-Chapelon, F.; Romieu, I. Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women. Am. J. Clin. Nutr.？2008, 87, 1384–1391. 18469262
[128]
Sieri, S.; Pala, V.; Brighenti, F.; Pellegrini, N.; Muti, P.; Micheli, A.; Evangelista, A.; Grioni, S.; Contiero, P.; Berrino, F.; Krogh, V. Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study. Am. J. Clin. Nutr.？2007, 86, 1160–1166. 17921397
[129]
Wen, W.; Shu, X.O.; Li, H.; Yang, G.; Ji, B.T.; Cai, H.; Gao, Y.T.; Zheng, W. Dietary carbohydrates, fiber, and breast cancer risk in Chinese women. Am. J. Clin. Nutr.？2009, 89, 283–289. 19056583
[130]
Polednak, A.P. Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers. Cancer Detect. Prev.？2008, 32, 190–199, doi:10.1016/j.cdp.2008.08.004. 18790577
[131]
Sears, W. Sugar and immunity. 2009. Available online: http://www.askdrsears.com/html/4/T045000.asp (accessed on 25 June 2010).
[132]
Johansen, D.; Borgstrom, A.; Lindkvist, B.; Manjer, J. Different Markers of Alcohol Consumption, Smoking and Body Mass Index in Relation to Risk of Pancreatic Cancer. A Prospective Cohort Study within the Malmo Preventive Project. Pancreatology？2009, 9, 677–686, doi:10.1159/000212088. 19684432
[133]
Platek, M.E.; Shields, P.G.; Marian, C.; McCann, S.E.; Bonner, M.R.; Nie, J.; Ambrosone, C.B.; Millen, A.E.; Ochs-Balcom, H.M.; Quick, S.K.; Trevisan, M.; Russell, M.; Nochajski, T.H.; Edge, S.B.; Freudenheim, J.L. Alcohol consumption and genetic variation in methylenetetrahydrofolatereductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk. Cancer Epidemiol. Biomarkers Prev.？2009, 18, 2453–2459, doi:10.1158/1055-9965.EPI-09-0159. 19706843
[134]
Poynter, J.N.; Haile, R.W.; Siegmund, K.D.; Campbell, P.T.; Figueiredo, J.C.; Limburg, P.; Young, J.; Le, M.L.; Potter, J.D.; Cotterchio, M.; et al. Associations between Smoking, Alcohol Consumption, and Colorectal Cancer, Overall and by Tumor Microsatellite Instability Status. Cancer Epidemiol. Biomarkers Prev.？2009, 18, 2745–2750, doi:10.1158/1055-9965.EPI-09-0517. 19755657
[135]
Gong, Z.; Kristal, A.R.; Schenk, J.M.; Tangen, C.M.; Goodman, P.J.; Thompson, I.M. Alcohol consumption, finasteride, and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Cancer？2009, 115, 3661–3669, doi:10.1002/cncr.24423. 19598210
[136]
Parsons, J.K.; Im, R. Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia. J. Urol.？2009, 182, 1463–1468, doi:10.1016/j.juro.2009.06.038. 19683313
[137]
Benedetti, A.; Parent, M.E.; Siemiatycki, J. Lifetime consumption of alcoholic beverages and risk of 13 types of cancer in men: Results from a case-control study in Montreal. Cancer Detect. Prev.？2009, 32, 352–362, doi:10.1016/j.canep.2009.03.001. 19588541
[138]
Flom, J.D.; Ferris, J.S.; Tehranifar, P.; Terry, M.B. Alcohol intake over the life course and mammographic density. Breast Cancer Res Treat.？2009, 117, 643–651, doi:10.1007/s10549-008-0302-0. 19184416
[139]
Guerrero, R.F.; Garcia-Parrilla, M.C.; Puertas, B.; Cantos-Villar, E. Wine, resveratrol and health: A review. Nat. Prod. Commun.？2009, 4, 635–658. 19445315
[140]
Wallenborg, K.; Vlachos, P.; Eriksson, S.; Huijbregts, L.; Arner, E.S.; Joseph, B.; Hermanson, O. Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. Exp. Cell Res.？2009, 315, 1360–1371, doi:10.1016/j.yexcr.2009.02.022. 19268663
[141]
Henderson, B. Testimonials. Beating Cancer Gently Web site, 2010. Available online: http://www.beating-cancer-gently.com/testimonials.html (accessed on 21 June 2010).
[142]
Page, S.; Mannion, C.; Heilman Bell, L.; Verhoef, M. CAM information online: An audit of Internet information on the “Bill Henderson Protocol”. Complement. Ther. Med.？2010, 18, 206–214, doi:10.1016/j.ctim.2010.07.003. 21056844
[143]
Angelo, L.S.; Kurzrock, R. Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia. Clin. Cancer Res.？2009, 15, 1123–1125, doi:10.1158/1078-0432.CCR-08-2791. 19228716
[144]
Lu, Q.Y.; Yang, Y.; Jin, Y.S.; Zhang, Z.F.; Heber, D.; Li, F.P.; Dubinett, S.M.; Sondej, M.A.; Loo, J.A.; Rao, J.Y. Effects of green tea extract on lung cancer A549 cells: Proteomic identification of proteins associated with cell migration. Proteomics？2009, 9, 757–767, doi:10.1002/pmic.200800019. 19137550
[145]
Ohno, S.; Ohno, Y.; Suzuki, N.; Soma, G.; Inoue, M. High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer. Anticancer Res.？2009, 29, 809–815. 19414313
[146]
Philips, B.J.; Coyle, C.H.; Morrisroe, S.N.; Chancellor, M.B.; Yoshimura, N. Induction of apoptosis in human bladder cancer cells by green tea catechins. Biomed. Res.？2009, 30, 207–215, doi:10.2220/biomedres.30.207. 19729851
[147]
Yeom, C.H.; Lee, G.; Park, J.H.; Yu, J.; Park, S.; Yi, S.Y.; Lee, H.R.; Hong, Y.S.; Yang, J.; Lee, S. High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis. J. Transl. Med.？2009, 7, 70, doi:10.1186/1479-5876-7-70. 19671184
[148]
Mousa, S.A. Antithrombotic effects of naturally derived products on coagulation and platelet function. Methods Mol. Biol.？2010, 663, 229–240. 20617421
