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菌物学报 2011
Recent progresses in the studies of taxol and taxane-producing fungi
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Abstract:
Paclitaxel (taxol?), a member of taxane family, has become a widely used anticancer drug in clinic. The industrial fermentation of taxol by fungi promises an effective way to increase the production and supply of the drug in the market. This review summarizes the latest results of the biodiversity of taxol-producing fungi, the fungal taxonomy, purification and characterization of fungal taxol, and molecular genetics of taxol biosynthesis.