Differential expression of analgesic proteins in two Paecilomyces gunnii isolates
两株古尼拟青霉菌株的镇痛差异蛋白质组学研究

Two isolates of Paecilomyces gunnii, anamorph of Cordyceps gunnii, with and without producing analgesic activity, were tested by using proteomic analysis in order to find the correlation between protein differential expression and analgesic activity. The results showed that expression of 51 protein spots significantly increased in the active isolate HZJ-1. Among the spots, structures of 39 proteins with various functions were identified. Most of the proteins were related to metabolism, and the NADP-specific glutamate dehydrogenase might mediate long-term depression of synaptic transmission and reduce pain. The functions of several conserved hypothetical proteins have not been reported, and are needed for further studies.