Effects of Fus3 RNAi on sporulation and cell wall composition synthesis in the dimorphic fungus Penicillium marneffei
RNA干扰Fus3基因对二态性真菌马尔尼菲青霉菌的孢子形成和细胞壁组分合成功能的影响

Penicillium marneffei is an important opportunistic pathogenic fungus causing a fatal systemic mycosis in patients infected with human immunodeficiency virus (HIV). Based on the genomic work and RNA interference, candidate virulence associated genes and virulence mechanisms are investigated to make it possible for overcoming the Penicillium marneffei infection. We characterized a novel Penicillium marneffei Fus3 gene, which is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonin...