A preliminary study of fresh Hericium erinaceus oral liquid on health-care function and promotion of learning and memory
鲜猴头菌口服液益智保健功效初步研究

The study was designed to investigate the toxicity of fresh Hericium erinaceus oral liquid and its treatment effects on learning and memory, DTH reaction in a mouse model of immunosuppression, and STZ-induced diabetes in a rat model. The results showed that the LD50 of fresh Hericium erinaceus oral liquid is higher than the dose of 27.2mL/kg. In the stay-down and stay-through assays, the time of latency and the number of errors made in the 5 minutes in the oral liquid-treated group was apparently less than those of the other groups. In the delayed type hypersensitivity (DTH) reaction, the swell of left back toes in the oral liquid-treated immunosuppressed mice was significantly bigger than that in the non-treatment immunosuppressed mice. In addition, the body weight of STZ-induced diabetic rats in the oral liquid-treated group was significantly improved in comparison with that before taking the oral liquid, and the haematological traits of diabetic rats in the oral liquid-treated group were not obvious as compared with those in the normal control group. The conclusion is that fresh Hericium erinaceus oral liquid is no toxicity, and it can significantly improve the ability of learning and memory, and strengthen the responses of the cellular immunity in mice. Besides, it can protect rats against STZ-induced diabetes.