Investigation of the effects of acidic extracts from Ganoderma lucidum fermentation broth on chronic bronchitis
灵芝发酵液酸性醇提物抗慢性支气管炎疗效的研究

The effects of acidic extracts from Ganoderma lucidum fermentation broth on chronic bronchitis in mice were investigated by expectorant, anti-tussive experiments and morphological observations. Ganoderma lucidum fermentation broth (GFB), different dosages of ethanol-extracts and butanol-extracts of GFB significantly prolonged the latent period of cough induced by SO2 and reduced the frequency of coughing, exhibiting obvious expectorant effect. Butanol-extracts with a dosage of 60mg/kg improved the excretion of phenol red by 50.7% as compared with controls, showing distinct antitussive effect over Honeysuckle-Scutellaria-Forsythia extract mixture oral liquid oral liquid. Ganoderic acidic extracts obviously alleviated the bronchial trauma of smoked mice, and the pathomorphological change was noticeably decreased as compared with the model group. However, the anti-inflammatory and anti-injury effects were equivalent to Honeysuckle-Scutellaria-Forsythia extract mixture oral liquid, which may provide the pharmacological basis for the development of Ganoderic acidic products.