Suppressors of sepH regulating cytokinesis of SIN pathway in Aspergillus nidulans
构巢曲霉胞质分裂SIN信号途径中sepH的反向调节子研究

As a member of septation initiation network (SIN), sepH is a key factor of cytokinesis in Aspergillus nidulans. However, how the suppressors of sepH affect cytokinesis is not yet understood. In this study, 116 mutants which suppressed the phenotype of sepH were isolated by UV mutation. These suppressors can restore septation and conidiation in the absence of the SEPH protein. By the cross and backcross, the temperature sensitive strain Sin110 was obtained and the bypass of SIN pathway was identified.