INVESTIGATIONS ON THE PATHOGENESIS OF GASTRIC CARCINOMA IN RELATION TO FUNGUS AND NITROGEN IN THE FOOD-CHAIN
真菌和氮素在食物链中与胃癌病因关系的探讨

It is believed that fungus and nitrogen may be introduced into the body through the process of food-chain. A carcinogic nitrose-compound may be synthesized by mycotoxin or other metabolites together with nitrites, guanidines and amines present in the stomath. Consequently, gastric carcinoma may be developed gradually in cases of chronic gastritis. It is under such hypothesis that the authors undertook a comprechensive survey of gastric carcinoma in areas of high as well as low incidence in our country. The result of this survey revealed that a high discovery rate of Aspergillus versicolor was found in the gastric juice of an empty stomach. The difference between the high and low incidence areas is significant statistically (p<0.001). Aspergillus versicolor was found to be closely associated with the pH value and the levels of acidity and NO_2 in the gastric juice. It was also well correlated with the results of biospy of gastric mucosa. It is already known that the sterigmate-cystin produced by Aspergillus versicolor may induce gastric adenocarcinoma in laboratory animals. Therefore, the authors assume that this fungus may have a definite association with human gastric carcinoma. Further studies are necessary to elucidate its role in the pathogenesis of the disease.