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Marine Drugs  2012 

Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi

DOI: 10.3390/md10071433

Keywords: Sarcophyton ehrenbergi, cembranoids, cytotoxicity, anti-HCMV

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Abstract:

In order to search for new bioactive substances from marine organisms, we have investigated the acetone extracts of the soft coral Sarcophyton ehrenbergi collected at San-Hsian-Tai, Taitong County, Taiwan. Chromatographic fractionation of the extracts of the octocoral S . ehrenbergi led to the isolation of three new cembranoids, (+)-12-ethoxycarbonyl-11 Z-sarcophine ( 1), ehrenbergol A and B ( 2 and 3). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, metabolites 1– 3 were evaluated in vitro for their cytotoxicity towards selected cancer cell lines and antiviral activity against human cytomegalovirus (HCMV).

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