MYCOSIS CAUSED BY ARTHRINIUM PHAEOSPERMUM,ITS ANIMAL TOXICITY AND PATHOLOGICAL ANALYSIS
我国首次发现的暗纹节菱孢所致皮肤真菌病的毒理实验及病理分析

This paper describes the results of animal toxicity test and pathological analysis of Arthrinium phaeospermum. The strain of Arthrinium phaeosprtmum was isolated fromthe skin lesions and the biopsy hssues of patients.The toxicity was tested on rabbits,guinea pigs and mice (LACA) with directly smearing the suspension of isolate, no skinlesion was found in 4 weeks; then with pricking the surface of skin and subcutaneous injection, tWo weeks later the lesion of infiltrative plagues, tubereules nade, subcutaneous abscesses occured on the skin and caused hair loss. When the suspension was injected intothe abdominal cavities of the tested animals, the mice died in two weeks, with small grayabscesses appeared in the peritoneum and mesentery.There are pathogenesis changes on theabdominal wall and liver, spleen, lung, kidney and heart. The guinea pigs were killed aftertwo weeks, and the pathogenesis changes are the same with as those found in the mice.The results showed that apparent pathological infiltrations were seen in the tissues.Thereare brown and red spores of various sizes and shapes in the infiltraction areas withpathological changes which are similar to those found in skin lesion of the patient, butshowed abscess granuloma with multinuclear giant cells which are rarely seen in skinlesiones of the patients.