β-Orcinol Metabolites from the Lichen Hypotrachyna revoluta

Four new β-orcinol metabolites, hypotrachynic acid (1), deoxystictic acid (2), cryptostictinolide (3) and 8 ？-methylconstictic acid (4) along with the metabolites 8 ？-methylstictic acid (5), 8 ？-methylmenegazziaic acid (6), stictic acid (7), 8 ？-ethylstictic acid (8) and atranorin (9), that have been previously described, were isolated for the first time from the tissue extracts of the lichen Hypotrachyna revoluta (Fl？rke) Hale. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analyses. Radical scavenging activity (RSA) of the metabolites isolated in adequate amounts, was evaluated using luminol chemiluminescence and comparison with Trolox？.