The First Guaian-12-oic Acid Glucopyranosyl Ester and Other Constituents from Picris rhagadioloides (L.) Desf. (Asteraceae)

The first guaian-12-oic acid glucopyranosyl ester was isolated from the roots ofPicris rhagadioloides (L.) Desf. (Asteraceae), in addition to five costuslactone-typeguaianolides, four germacranolides and three phenolic compounds. This is the first timethat the known phenolics syringaldehyde and syringaresinol, as well as the knownsesquiterpene lactones glucozaluzanin C, cichorioside C and hypochoeroside A have beendescribed from a Picris species. The compounds were characterized on the basis ofphysicochemical, 1D- and 2D-NMR spectroscopic, and mass spectrometric data.