STUDY OF IN VITRO ANTICOAGULANT PROPERTY OF THE La ADDED MEDICAL 316L STAINLESS STEEL
含La医用316L不锈钢的体外抗凝血性能研究

The in vitro anticoagulant property of a medical grade 316L stainless steel with 0.05% La addition was systematically studied. The results showed that, compared with the conventionally used medical 316L stainless steel, the La added 316L steel possesses less platelets adhesion and less activation of the platelets, and their kinetic clotting time and the plasma recalcification time become longer, which reveals that the activation extent of the latter on intrinsic coagulation factors is smaller than the former and the anticoagulant property of the latter is better. Through measurement of the contact angles of the steels, and calculations of the surface tension of the steels and the interfacial tension between the steels and the blood, the anticoagulant mechanism of the steels was analyzed from the viewpoint of surface energy.