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Molecules  2002 

An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone

DOI: 10.3390/70200129

Keywords: Carvone, 3β-hydroxycarvone, silyl enol ether, stereoselective synthesis

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Abstract:

(-)-Carvone (3) has been efficiently transformed into (-)-3β-hydroxycarvone (1), which is expected to be a useful synthon or chiral template in the synthesis of natural molecules. This short and efficient synthesis of compound 1 involves regioselective and stereoselective α-hydroxylation of carvone via the trimethylsilyl-dienyl-ether derivative.

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