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Molecules  2002 

Lithium Perchlorate Mediated Three-Component Preparation of Primary Aminoesters

DOI: 10.3390/70100072

Keywords: Primary aminoesters, Lithium perchlorate, Mannich reaction

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Abstract:

A three-component reaction between an aldehyde, metallated hexamethyldisilazane and a functionalized organozinc compound proceeded smoothly in the presence of LiClO4 in diethyl ether to afford primary amino esters in good yields.

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