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Molecules 2002
Reactivity of 3-Ethoxycarbonyl Isoquinolinium Salts Towards Various Nucleophilic Reagents: Applications to the Synthesis of New 1,2-Dihydroisoquinoline-3-carboxylatesDOI: 10.3390/70200252 Keywords: 1, 2-dihydro isoquinoline, lipophilic isoquinolinium, solvent-free quaternization, organolithium, alcoholate, N, O-acetal, domino reaction Abstract: Different types of novel 1,2-disubstituted 1,2-dihydro isoquinolines were synthesized by addition reactions of organolithium, alcoholates and borohydride reagents with various isoquinolinium salts. The leaving group character of the isoquinoline moiety was also evidenced.
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