The effects of degrees of deacetylation, molecular weights and states of chitosans on procoagulant activities in vitro
壳聚糖的脱乙酰度、分子质量和性状对其体外促凝血活性的影响

To investigate the effects of degrees of deacetylation, molecular weights and states (solutions or solid powder) of chitosans on the procoagulant activities in vitro, the blood clotting time of the samples with different concentrations, properties and states were tested the in tube method. When molecular weights were close, the blood clotting time of chitosan solutions decreased with the increasing of degree of deacetylation, however, the procoaglant ability of the chitosan powder with medium degree of deacetylation was the best of all. When degrees of deacetylation were close, the solution of chitosan with high molecular weight was the only one that had procoagulant activity, but all the powders could decrease the clotting time in vitro. All solid chitosan powders, except the one with high degree of deacetylation and molecular weight, promoted the blood coaglations more efficiently than the correspondent solution at the same concentration.