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环境科学学报 2011
Acute toxicity of imidazolium ionic liquid to mice
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Abstract:
The acute toxicity to mice of imidazolium ionic liquids (ILs) with varying alkyl chain lengths was evaluated by Karber's modified method and hepatic lesions were observed by hematoxylin-eosin staining. The results showed that four types of ILs including C10mim]Br,C12mim]Br,C14mim]Br and C18mim]Br produced obvious hepatic lesions in mice,and the LD50 of the ILs ranged from 98.91 to 220.16 mg·kg-1,indicating a medium toxicity. The acute toxicity of different ILs to mice was related to the length of its side chain,and the strongest toxicity was observed for the ILs with the alkyl chain length of fourteen.
