Effects of dust storm fine particles (PM2.5) on micronuclei formation of human blood lymphocytes
沙尘暴细颗粒物对人外周血淋巴细胞微核形成的影响

The effects of dust storm and normal ambient air fine particles (PM2.5) and their organic and inorganic extracts from Baotou city and Wuwei city on micronuclei formation of human blood lymphocytes were invested using cytochalasin B blocked test. The results showed that dust storm and normal ambient air PM2.5 and their organic extracts had marked genetic toxicity on lymphocytes. With the increase of treatment concentrations the micronuclei frequency (MNF) increased and the nuclear division index (NDI) values declined in a dose-response manner(p<0.01). Although the inorganic extracts showed dose-response manner but there was no marked difference among the treatments(p>0.05). In the same concentrations, the treatments of dust storm samples and normal samples were not significant different (p>0.05) except the treatments of normal ambient air PM2.5 from Baotou city and its organic extracts were significant higher than those of dust storm(p<0.01). The treatments of normal ambient air PM2.5 from Baotou city and its organic extracts were significant higher than those of Wuwei city, but the treatments of dust storm PM2.5 and its extracts were not significant different between the cities.