Study on DNA-DNA crosslinks induced by air formaldehyde in mice liver
气态甲醛致小白鼠肝脏DNA-DNA交联的研究

In order to explore the effect of DNA-DNA crosslinks and estimate the genotoxicity induced by formaldehyde, this study used Kunming mice as the experiment objects, which were exposed to the air formaldehyde in 72 hours. This experiment applied fluorescence measurement to detect DNA-DNA crosslinks formation effect of the liver cells of the mice after the exposure to air formaldehyde. Results show that 0.5 mg·m-3 air formaldehyde can induce DNA-DNA crosslinks formation in vivo (p<0.05), and in a dose-dependent manner at higher concentrations (1.0 mg·m-3, 3.0 mg·m-3,p<0.01). Air formaldehyde exposure, even as low as 0.5 mg·m-3, induced DNA-DNA crosslinks in mice liver easily, and the effect level is taken in a dose-dependent manner within 3.0 mg·m-3 range.