Oxidation damage of sulfur dioxide derivatives on human red blood cells and the protection role of vitamin C
SO2体内衍生物对人血红细胞的氧化损伤及其防护

To study the toxicological role of SO2 on mammalian cells and its protection. After treated by i.p. sulfur dioxide derivatives (sodium hydrosulfite and sodium sulfite 3:1,mol·L-1 / mol·L-1) or/and vitamin C, the activities of CAT(catalase), SOD (superoxide dismutase) and the level of lipid peroxidation (LPO)in human red blood cells were investigated. Results showed that (1) After treated solely by sulfur dioxide derivatives, the activities of CAT and SOD were significantly decreased, the levels of LPO were increased significantly. (2) Vc caused increase of the activities of SOD and CAT, but not significant. And it caused significant decrease of the level of LPO except for the 0.05 mmol·L-1 vitamin C group. (3) After treated synchronously by Vc 0.1mmol·L-1 and different dose derivatives of sulfur dioxide, Vc decreased level of LPO and increased the activities of CAT and SOD in the red blood cells treated by derivatives of sulfur dioxide. It is suggested that derivatives of sulfur dioxide might cause the decreases of CAT and SOD activities and the increases of LPO levels in human red blood cells, Vc has protection role for it.