STUDIES ON THE RELATIONSHIP BETWEEN LIPID PEROXIDATION INDUCED BY GAS-PHASE OF CIGA-RETTE SMOKE AND RESPIRATORY BURST OF GRANULOCYTES
香烟气相物质引发的脂质过氧化与粒细胞呼吸爆发关系的ESR研究

The effect of the peroxidized liposomes on the respiratory burst of rat peritoneal granulocytes (PRGs) was investigated by using ESR spin trapping technique with DMPO (5,5-dimethyl-pyrrolinelN-oxide). The results showed that the liposomes at a proper degree of lipid peroxidation was able to increase the production of superoxide anions by PRGs under the stimulation of PMA (phorbol 12-myristate 13-acetate). Liposomes with the concentration of 0.5mg/ml firstly gave that effect going up with the smoke bubbling time, and the maximum was reached after about 30 seconds of smoke bubbling, then going down gradually. The air-peroxidized liposomes had similar effectson the respiratory burst of PRGs.