PREPARATION OF COLLAGEN-SULFONATED CARBOXYMETHYL CHITOSAN/SILICONE MEMBRANE BILAYER DERMAL EQUIVALENT AND ITS APPLICATION IN THE TREATMENT OF SCALDS OF PORCINE SKIN
胶原-磺化羧甲基壳聚糖/硅橡胶皮肤再生材料的制备及其对小型猪烫伤创面全层皮肤缺损的修复研究

A dermal equivalent applied in the treatment of scalds has been attracting much attention.We report here the fabrication of a bilayer dermal equivalent(BDE) composed of collagen-sulfonated carboxymethyl chitosan(SCC) porous scaffold and silicone membrane,and its application for accelerating the healing of skin scalds in a Bama miniature pig model.Firstly,the SCC was synthesized,and its chemical structure was characterized by FTIR and ~1H-NMR.Then the effect of the ratio of the SCC on the microstructure of t...